abstract：:It is well-known that leukemic cells of overt leukemia (OL) that have transformed from myelodysplastic syndromes (MDS) are more resistant to chemotherapy as compared with de novo AML cells. Thus, to examine the expression levels of drug-resistant genes and their alterations with the development of OL in MDS, the expre...

journal_title：Experimental and molecular pathology

authors： Kurata M,Hasegawa M,Nakagawa Y,Abe S,Yamamoto K,Suzuki K,Kitagawa M

更新日期：2006-12-01 00:00:00

abstract：:Oral cancer is a major health problem in many parts of the world including India. The molecular mechanisms involved in oral tumorigenesis are not completely understood. Although surgery continues to be the most common treatment modality for this cancer, survival rates of oral cancer patients have still not significant...

journal_title：Experimental and molecular pathology

authors： Santhi WS,Sebastian P,Varghese BT,Prakash O,Pillai MR

更新日期：2006-10-01 00:00:00

abstract：:The purpose of this study was to look for associations between a newly described class of suppressors of cytokine signaling (SSI/SOCS) and cytokine expression in the uterine cervix from HIV/HPV coinfected women. We examined the pro-inflammatory cytokines TNF-alpha and IL-6 since their expressions are linked and respon...

journal_title：Experimental and molecular pathology

authors： Nicol AF,Nuovo GJ,Wang Y,Grinsztejn B,Tristão A,Russomano F,Perez MA,Lapa e Silva JR,Fernandes AT,Gage JR,Martínez-Maza O,Bonecini-Almeida MG

更新日期：2006-08-01 00:00:00

abstract：:Platelet Endothelial Cell Adhesion Molecule (PECAM) is an adhesion and signaling molecule used for leukocyte extravasation. We have generated two strains of PECAM-deficient mouse, one in the original C57BL/6 and a second by backcrossing nice generations into the FVB/n strain. The FVB/n strain has reduced responses in ...

journal_title：Experimental and molecular pathology

authors： Schenkel AR,Chew TW,Chlipala E,Harbord MW,Muller WA

更新日期：2006-08-01 00:00:00

abstract：:Two basic models of alcoholic liver disease pathogenesis exist, one in vivo and one in vitro. To justify the in vitro model, evidence is needed to show that it stimulates the in vivo model. Therefore, changes in gene expression caused by high ethanol level were compared using the two models. Many functional pathways w...

journal_title：Experimental and molecular pathology

authors： Bardag-Gorce F,French BA,Dedes J,Li J,French SW

更新日期：2006-06-01 00:00:00

abstract：:Paraoxonase gene polymorphisms (PON1-55 and PON1-192) were determined in four Mexican populations (Mestizos, Nahuas, Teenek and Mayos) belonging to different ethnic groups. The role of these polymorphisms in the lipid profile in the Mestizo group was also analyzed. PON1 polymorphisms were determined by polymerase chai...

journal_title：Experimental and molecular pathology

authors： Gamboa R,Zamora J,Rodríguez-Pérez JM,Fragoso JM,Cardoso G,Posadas-Romero C,Vargas-Alarcón G

更新日期：2006-02-01 00:00:00

abstract：:The molecular alterations involved in the pathogenesis of gallbladder cancer are not yet well defined. Our aim was to determine the microsatellite status of gallbladder carcinomas and its possible correlation with alterations in K-ras and p53 genes as well as the clinicopathological characteristics of these tumors. A ...

journal_title：Experimental and molecular pathology

authors： Saetta AA,Gigelou F,Papanastasiou PI,Koilakou SV,Kalekou-Greca H,Miliaras D,Michalopoulos NV,Patsouris E

更新日期：2006-02-01 00:00:00

abstract：:Cell death caused by the accumulation of extracellular adenosine is believed to contribute to the profound loss of T lymphocytes in patients with severe combined immunodeficiency disease due to adenosine deaminase deficiency. Although adenosine is known to trigger apoptosis in thymocytes and peripheral T cells, the mo...

journal_title：Experimental and molecular pathology

authors： El-Darahali A,Fawcett H,Mader JS,Conrad DM,Hoskin DW

更新日期：2005-12-01 00:00:00

abstract：:We previously reported the expression profiles of 9 cytochrome P450 isozymes (CYPs) proteins and those of 40 CYPs genes in pregnant rat's liver, placenta and fetal liver after treatment with pregnenolone-16alpha-carbonitrile (PCN) or phenobarbital (PB). This study was carried out focusing on the gene expression profil...

journal_title：Experimental and molecular pathology

authors： Ejiri N,Katayama K,Kiyosawa N,Baba Y,Doi K

更新日期：2005-12-01 00:00:00

abstract：:The parent-into-F1 mouse model (P-->F1) of acute graft-vs.-host disease (GVHD) is a useful model of human acute GVHD because it allows the study of the T cell contribution to pathology without the complicating effects of conditioning regimens. To determine the similarity of this model to human GVHD, we assessed injury...

journal_title：Experimental and molecular pathology

authors： Niculescu F,Niculescu T,Nguyen P,Puliaev R,Papadimitriou JC,Gaspari A,Rus H,Via CS

更新日期：2005-10-01 00:00:00

abstract：:The prognostic significance of selected markers of leukemic cells is well known. CD7 and CD56 expression at diagnosis has been associated with low remission rates and biological aggressiveness in a significant proportion of acute leukemias. Among 46 patients with acute myeloid leukemia, we found CD7 expression in 15 c...

journal_title：Experimental and molecular pathology

authors： Cruse JM,Lewis RE,Pierce S,Lam J,Tadros Y

更新日期：2005-08-01 00:00:00

abstract：:Integrins are a family of cell surface glycoproteins that act as receptors for ECM proteins or for membrane bound counter-receptors on other cells. The integrin receptor family of vertebrates includes at least 16 distinct alpha subunits and at least 8 beta subunits which can associate to form more than 20 distinct int...

journal_title：Experimental and molecular pathology

authors： Blundell RA,Harrison DJ

更新日期：2005-08-01 00:00:00

abstract：:Obliterative bronchiolitis is the major complication affecting long-term lung transplant survivors. Tumor necrosis factor-alpha (TNF-alpha) promotes inflammation and fibrosis in chronic lung injury models. These experiments defined the role of TNF-alpha in an established model of obliterative airway disease (OAD). Rat...

journal_title：Experimental and molecular pathology

authors： Farivar AS,Mackinnon-Patterson B,McCourtie AS,Namkung J,Ward PA,Mulligan MS

更新日期：2005-06-01 00:00:00

abstract：:Sabaeksan has been used for prevention and treatment of bronchial asthma and allergic asthma in Korea. To investigate the biological effect of Sabaeksan, we examined the effect of Sabaeksan on the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-induced pro-inflammatory cytokines secretion in human m...

journal_title：Experimental and molecular pathology

authors： Choi IY,Koo HN,Lee SH,Shin JY,Chae HJ,Kim HR,Kim CH,Hong SH,Kim HM

更新日期：2005-06-01 00:00:00

abstract：:Osteonecrosis of the femoral head was produced in rats by cutting the ligamentum teres and incising the cervical periosteum. As of the second postoperative week, fibrous tissue pervaded the necrotic epiphyses, macrophages and osteoclasts removed the debris, osteoblasts deposited lamellar-fibred and woven-fibred intram...

journal_title：Experimental and molecular pathology

authors： Bejar J,Misselevich I,Peled E,Zinman C,Reis DN,Boss JH

更新日期：2005-04-01 00:00:00

abstract：:The hypoxia-inducible factor-1alpha (HIF-1alpha) is expressed in response to hypoxia and has been recently demonstrated in a variety of cells such as tumor cells and tumor-associated macrophages. Several characteristics of leishmanial lesions in humans and in animal models, such as microcirculation impairment, metabol...

journal_title：Experimental and molecular pathology

authors： Arrais-Silva WW,Paffaro VA Jr,Yamada AT,Giorgio S

更新日期：2005-02-01 00:00:00

abstract：:The aim of this study is to determine if warm ischemia after surgical extirpation impacts gene expression in tissue samples which will be used for cDNA array analysis. We investigated effects of warm ischemia on gene expression in lung, liver, kidney, and spleen of rats, chronologically, using an original cDNA array, ...

journal_title：Experimental and molecular pathology

authors： Miyatake Y,Ikeda H,Michimata R,Koizumi S,Ishizu A,Nishimura N,Yoshiki T

更新日期：2004-12-01 00:00:00

abstract：:We have investigated the incidence of the C677T and A1298C methylene tetrahydrofolate reductase (MTHFR) gene single nucleotide polymorphisms (SNPs) in the South Indian Tamil Nadu population with a total number of 72 individuals. The MTHFR genotyping was performed using the polymerase chain reaction followed by restric...

journal_title：Experimental and molecular pathology

authors： Angeline T,Jeyaraj N,Granito S,Tsongalis GJ

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Existing clinical data have shown that high-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor to prostate cancer (CaP). Criteria to distinguish HGPIN that progress to CaP from those that do not remain poorly defined. Our objective was to evaluate microvessel density as a molecula...

journal_title：Experimental and molecular pathology

authors： Sinha AA,Quast BJ,Reddy PK,Lall V,Wilson MJ,Qian J,Bostwick DG

更新日期：2004-10-01 00:00:00

abstract：:Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative diseases of man and animals and are transmitted by a filterable pathogen whose identity is currently unresolved. Our data indicates that Spiroplasma, a wall-less bacterium, is involved in the pathogenesis of TSE. We searched for Spiroplasma ri...

journal_title：Experimental and molecular pathology

authors： Bastian FO,Dash S,Garry RF

更新日期：2004-08-01 00:00:00

abstract：:Recent studies have demonstrated important pro-inflammatory roles for two matrix metalloproteinases (MMPs)-MMP-3 (stromelysin-1) and MMP-9 (gelatinase B)-in acute lung injury [Am. J. Respir. Cell Mol. Biol. 24 (2001) 1]. A role for MMP-3 in skin inflammation has also been demonstrated [Proc. Natl. Acad. Sci. U. S. A. ...

journal_title：Experimental and molecular pathology

authors： Warner RL,Bhagavathula N,Nerusu KC,Lateef H,Younkin E,Johnson KJ,Varani J

更新日期：2004-06-01 00:00:00

abstract：:Deletion in the 22.9 -Mb chromosomal (chr.) 8p21.3-23 region has been shown to be necessary for the development of breast carcinoma (CaBr). In this study, we have attempted to detect the minimal deleted region(s) in the chr.8p21.3-23 region in 62 primary breast lesions having 56 CaBr tumors and six other breast lesion...

journal_title：Experimental and molecular pathology

authors： Bhattacharya N,Chunder N,Basu D,Roy A,Mandal S,Majumder J,Roychowdhury S,Panda CK

更新日期：2004-06-01 00:00:00

abstract：:Uveitis is an inflammation of the uveal tract and is one of the major causes of visual impairment. Several lines of evidence suggest an important role for activated T lymphocytes in the perpetuation of posterior uveitis. In sequel to our preliminary observations with human S-antigen, we have further investigated the p...

journal_title：Experimental and molecular pathology

authors： Tripathi P,Saxena S,Yadav VS,Naik S,Singh VK

更新日期：2004-04-01 00:00:00

abstract：:Although clinical diabetes mellitus is obviously a high risk factor for myocardial infarction, there is disagreement about the sensitivity of ischemic injury of an infarcted myocardium in experimental studies. The present study evaluated the influences of different durations of hyperglycemia on ischemic and reperfusio...

journal_title：Experimental and molecular pathology

authors： Xu G,Takashi E,Kudo M,Ishiwata T,Naito Z

更新日期：2004-02-01 00:00:00

abstract：:Retinoids influence the pathogenesis of alcohol liver disease (ALD). To analyze the impact of retinoid X receptor alpha (RXRalpha) on ALD, alcohol-induced hepatotoxicity was studied using mice fed ethanol intragastrically for 25 days. Alcohol-induced microvesicular fat around the central vein and drug-induced morpholo...

journal_title：Experimental and molecular pathology

authors： Dai T,Wu Y,Leng AS,Ao Y,Robel RC,Lu SC,French SW,Wan YJ

更新日期：2003-12-01 00:00:00

abstract：:Ureaplasma urealyticum is a common inhabitant of mucosal surfaces but is also associated with a higher incidence of pneumonia and bronchopulmonary dysplasia in preterm infants. Culture and polymerase chain reaction demonstrate high isolation rates of ureaplasma in clinical specimens documenting their presence but do n...

journal_title：Experimental and molecular pathology

authors： Benstein BD,Crouse DT,Shanklin DR,Ourth DD

更新日期：2003-10-01 00:00:00

abstract：:Endothelial cell activation and proliferation are the essential steps in flow-induced arterial remodeling. We investigated endothelial cell turnover in the early stages of high-flow in the rabbit common carotid arteries using an arteriovenous fistula (AVF) model by kinetic investigation of cell proliferation and cell ...

journal_title：Experimental and molecular pathology

authors： Sho E,Komatsu M,Sho M,Nanjo H,Singh TM,Xu C,Masuda H,Zarins CK

更新日期：2003-08-01 00:00:00

abstract：:The N-methyl-D-aspartate receptor (NMDAR), which is one of the glutamate receptors, is considered to have a close relationship to synaptic plasticity in the developing brain. In addition, it is known that the excessive stimulation of NMDARs can trigger neuronal apoptosis. In this study, we examined the distribution of...

journal_title：Experimental and molecular pathology

authors： Takai H,Katayama K,Uetsuka K,Nakayama H,Doi K

更新日期：2003-08-01 00:00:00

abstract：:Experimental autoimmune myositis (EAM) is a rodent model for human inflammatory muscle disease (IMD). It can be induced by immunization of rodents with skeletal muscle homogenate and adjuvant. The specific myositogenic autoantigen has not been clearly identified although some evidence points to skeletal muscle myosin....

journal_title：Experimental and molecular pathology

authors： Nemoto H,Bhopale MK,Constantinescu CS,Schotland D,Rostami A

更新日期：2003-06-01 00:00:00

abstract：:TNF-alpha is a proinflammatory cytokine, abundantly expressed after myocardial infarction. It has been suggested that it exhibits myocardial suppressive and cytotoxic effects. AG-556 is a tyrosine kinase inhibitor synthesized based on its ability to reduce TNF-alpha production and cell toxicity, and to improve experim...

journal_title：Experimental and molecular pathology

authors： George J,Biner S,Keren P,Barshack I,Goldberg I,Sherez J,Levitzki A,Keren G,Roth A

更新日期：2003-06-01 00:00:00

abstract：:Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into precancerous clones. Over the past decade many studies have revealed the r...

journal_title：Experimental and molecular pathology

authors： Bishop AJ,Schiestl RH

更新日期：2003-04-01 00:00:00

abstract：:The skin presents a mechanical, as well as an immunological barrier to infection, and displays considerable innate immune capacity. Recently, cultured human keratinocytes were described to produce and export a microbicidal peptide human beta-defensin 2 (HBD-2). Immunogold was used to label ultrathin cryosections of st...

journal_title：Experimental and molecular pathology

authors： Oren A,Ganz T,Liu L,Meerloo T

更新日期：2003-04-01 00:00:00

abstract：:Lumican is a member of a small leucine-rich proteoglycan family. We previously found that lumican mRNA and its protein were ectopically and highly expressed in acinar cells in chronic pancreatitis (CP)-like lesions close to pancreatic cancer cells. CP-like lesions are characterized by acinar and ductal-ductular cell p...

journal_title：Experimental and molecular pathology

authors： Naito Z,Ishiwata T,Lu YP,Teduka K,Fujii T,Kawahara K,Sugisaki Y

更新日期：2003-02-01 00:00:00

abstract：:Mononuclear cell infiltration of the thyroid is a prominent feature of chronic lymphocytic thyroiditis. Adhesion molecules play a major role in determining the localization of inflammatory mononuclear cells in the thyroid. Previous reports from animal models and human studies have described the thyroidal expression of...

journal_title：Experimental and molecular pathology

authors： Bonita RE,Rose NR,Rasooly L,Caturegli P,Burek CL

更新日期：2002-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an aggressive inflammatory disease in which chemokines are thought to recruit leukocytes and induce angiogenesis. The aim of this study was to investigate the effects of sulfasalazine (SASP) and its metabolites, sulfapyridine (SP), and 5-aminosalicylic acid (5ASA) on chemokine production b...

journal_title：Experimental and molecular pathology

authors： Volin MV,Campbell PL,Connors MA,Woodruff DC,Koch AE

更新日期：2002-10-01 00:00:00

abstract：:We previously reported that antibodies to squalene, an experimental vaccine adjuvant, are present in persons with symptoms consistent with Gulf War Syndrome (GWS) (P. B. Asa et al., Exp. Mol. Pathol 68, 196-197, 2000). The United States Department of Defense initiated the Anthrax Vaccine Immunization Program (AVIP) in...

journal_title：Experimental and molecular pathology

authors： Asa PB,Wilson RB,Garry RF

更新日期：2002-08-01 00:00:00

abstract：:To assess elastin biosynthesis in the aortic wall in response to acute elevation of blood pressure, we studied the aortic gene expression of tropoelastin in a rabbit midthoracic aortic coarctation model. The time points of the study were 1, 3, and 7 days and 2, 4, and 8 weeks after coarctation. Additional animals were...

journal_title：Experimental and molecular pathology

authors： Xu C,Zarins CK,Glagov S

更新日期：2002-04-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is a clinical syndrome that is characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or noninfectious insult. In this report we describe a unique animal model in which CBA/J ...

journal_title：Experimental and molecular pathology

authors： London L,Majeski EI,Paintlia MK,Harley RA,London SD

更新日期：2002-02-01 00:00:00

abstract：:Several growth factors are actively synthesized during wound repair and function to stimulate different cell types involved in the process of healing. Fibrosin is a novel fibrogenic lymphokine that stimulates several biological activities that relate to in vivo scarring. To investigate the role of fibrosin, we used "p...

journal_title：Experimental and molecular pathology

authors： Prakash S,Robbins PW

更新日期：2001-12-01 00:00:00

abstract：:Piecemeal necrosis, currently called interface hepatitis, is a feature of viral hepatitis as well as autoimmune hepatitis and steatohepatitis. The mechanism of liver cell loss and piecemeal necrosis needs to be determined. We hypothesize that piecemeal necrosis in hepatitis is due to a piecemeal removal of hepatocyte ...

journal_title：Experimental and molecular pathology

authors： Wang MX,Morgan T,Lungo W,Wang L,Sze GZ,French SW

更新日期：2001-10-01 00:00:00